22: Risk Factors for Death Due to Primary Graft Dysfunction in Adult Lung Transplantation

Abstract

preoperative weight, and a diagnosis of PPH or IPF. In multivariable analyses, most variables (such as use of bypass) lost association with PGD when adjusted for pulmonary arterial pressures. Three variables were independently associated with PGD: elevated PASP, odds ratio (OR) for each 10 mmHg 1.46 (95% CI 1.17, 1.82; p 0.001); diagnosis of IPF, OR relative to COPD 4.60 (95% CI 1.53, 13.9; p 0.007); and intraoperative platelet transfusion, OR per unit 1.19 (95% CI 1.01, 1.40; p 0.033). Conclusions: Higher pulmonary artery pressures are a risk factor for PGD independent of diagnosis and therapeutic variables. IPF also appears to confer an increased risk for PGD, independent of other variables including procedure type.