Abstract
Cyclopropane is often present in natural and biologically active products. Alternatively, the cyclopropane structure has been used as parts for the modification of such products. It has a high ring strain because of its bond angle, and this property facilitates unique reactions. This chapter collects recent representative examples of [2+1]-type cyclopropanation reactions. Specifically, it reviews six categories of reactions: Michael-induced ring closure (MIRC) reaction, the Simmons-Smith reaction, reactions by carbenes from diazo-alkanes catalyzed/noncatalyzed by transition metals, cyclo-isomerization reactions by transition metal catalysts, the Kulinkovich reaction, and miscellaneous reactions. The asymmetric synthesis of cyclopropanes, which is a topic of interest among synthetic chemists, is discussed in each category.
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