Abstract
Stem bark of Hippocratea excelsa afforded six pentacyclic triterpenes, five oleanane and one ursane types. They were identified as 11β,21β-dihydroxy-olean-12-ene-3-one ( 2), 3α,11α,21β-trihydroxy-olean-12-ene ( 3), 3α,21β-dihydroxy-11α-methoxy-olean-12-ene ( 4), 3α,21β-dihydroxy-olean-9(11),12-diene ( 5), 3α,21β-dihydroxy-olean-12-ene ( 6) and 3α,21β-dihydroxy-11α-methoxy-urs-12-ene, isolated as its diacetate derivative ( 7), as well as 3α,21β-dihydroxy-olean-12-ene ( 1) previously isolated from the root bark. The known α- and β-amyrin, oleanoic and ursolic acids, trans-polyisoprene, and the ubiquitous β-sitosterol were also isolated. Structures were elucidated on the basis of spectroscopic analyses, including homo- and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC and HMBC) and comparison with literature data. The antigiardial activity of compounds 2– 5 was not significant.
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