Abstract
Analysis of T-cell repertoire (TCR) has been proposed as a new approach to better understand the adaptive immune response in cancer diseases. Next generation sequencing of the TCR has proven to be a powerful approach to characterize this repertoire, with potential applications to select and follow patients who benefit from immunomodulatory therapies. However, current TCR sequencing in tumor tissues is based on bulk RNA or DNA extraction, which does not provide neither the functional information at the clonotype level nor the spatial context.
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