2194. Epidemiology, Clinical Features and Outcomes of Hospitalized Adult Patients with Respiratory Syncytial Virus Infections

Abstract

Abstract Background Respiratory Syncytial Virus (RSV) is a common cause of respiratory tract infection (RTI) in all age groups. In general, RSV causes more severe disease in the elderly and adults with underlying comorbidities. There are limited studies evaluating RSV disease among inpatient adults. Our study objective was to assess the epidemiology, clinical features and outcomes of RSV RTIs among hospitalized adults. Methods A multicenter retrospective cohort study was conducted on adult patients hospitalized for RSV RTIs in southeast Michigan from 1/1/19-12/31/21. Hospitalized patients were identified using ICD 10 codes for RSV related diseases. Electronic medical records were reviewed. We collected the following data: demographics, comorbid conditions, laboratory and radiology results, treatment received and outcomes (death, discharge, 30 day readmission). Results A total of 102 patients were identified and included for analysis. The mean (SD) age of the cohort was 68.8 ± 14.2 yrs, 61 (60%) were female and 60 (59%) were white. The mean body mass index of the cohort was 31 ± 9.5 kg/m2. The common comorbidities were chronic lung disease (75%), hypertension (69%), obesity (38%) and congestive heart failure (30%). The mean Charlson weighted index of comorbidity was 2.28 ± 2. Fever and hypotension were noted in 13% and 15% on admission respectively. Admission CXR were abnormal in 47% cases. RSV upper and lower RTI were present in 23 (22.5%) and 79 (77.5%) respectively. Antibiotics were given in 63% of patients. Infectious diseases consultation was obtained in 41% cases. Mechanical ventilation was required in 11%, intensive care in 23.5% patients and length of stay was 6.5 + 5.6 days. Other complications were encephalopathy in 17%, acute kidney injury in 21% and liver injury in 5%. Seven (6.8%) patients died. Conclusion Our study found that adults admitted with RSV tended to be elderly, have multiple comorbid conditions and a high incidence of lower RTIs. Admissions were frequently complicated by need for ICU stay, mechanical ventilation and death. Our study supports a need for RSV immunizations once available for this high risk population. Disclosures All Authors: No reported disclosures.