219 (PB099) - The RNA-Binding Protein with Multiple Splicing (RBPMS) splice variants A and C, acts as a tumor suppressor gene in ovarian cancer

Abstract

RNA-Binding Protein with Multiple Splicing (RBPMS) is a member of a family of proteins that bind to nascent RNA transcripts and regulate their processing, and stability of the RNA molecules. Evidence indicates that RBPMS also control de activity of transcription factors associated with cell proliferation including AP-1 and STATs. Three major RBPMS protein splice variants have been described in the literature: RBPMSA, RBPMSB, and RBPMSC. We previously reported that reduced RBPMS levels decreased the sensitivity of ovarian cancer (OC) cells to cisplatin treatment.