Abstract
Fetal wound healing is characterized by regeneration with a diminished inflammatory response, minimal fibroplasia, and restoration of normal tissue architecture. In contrast, adult wound healing is characterized by inflammation and scar formation. Fetal wounds also have increased content of high molecular weight hyaluronic acid (HMW-HA) in the extracellular matrix (ECM). HMW-HA has been shown to have anti-inflammatory properties. We have recently shown that decreased inflammation in adult wounds, mediated by IL-10 overexpression, can promote scarless or regenerative healing. We hypothesized that overexpression of HAS-1, the enzyme responsible for producing HMW-HA, in adult dermal wounds would result in decreased inflammation and promote scarless or regenerative healing.
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