218 INTERACTIONS BETWEEN DIET AND THE C161T POLYMORPHISMS IN THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPAR-γ) GENE IN PROSTATE CANCER RISK IN JAPANESE MEN

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History (I)1 Apr 2013218 INTERACTIONS BETWEEN DIET AND THE C161T POLYMORPHISMS IN THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPAR-γ) GENE IN PROSTATE CANCER RISK IN JAPANESE MEN Ryosuke Ando, Teruo Nagaya, Sadao Suzuki, Toshiki Etani, Taku Naiki, Noriyasu Kawai, Keiichi Tozawa, Shinkan Tokudome, and Kenjiro Kohri Ryosuke AndoRyosuke Ando Nagoya, Japan More articles by this author , Teruo NagayaTeruo Nagaya Nagoya, Japan More articles by this author , Sadao SuzukiSadao Suzuki Nagoya, Japan More articles by this author , Toshiki EtaniToshiki Etani Nagoya, Japan More articles by this author , Taku NaikiTaku Naiki Nagoya, Japan More articles by this author , Noriyasu KawaiNoriyasu Kawai Nagoya, Japan More articles by this author , Keiichi TozawaKeiichi Tozawa Nagoya, Japan More articles by this author , Shinkan TokudomeShinkan Tokudome Tokyo, Japan More articles by this author , and Kenjiro KohriKenjiro Kohri Nagoya, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1598AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The C161T polymorphism in the peroxisome proliferator-activated receptor gamma (PPAR-γ) gene has been associated with a reduced risk for coronary artery disease and colorectal adenomas. However, the relationship between C161T polymorphism and cancer risk appears limited and controversial. We examined the associations of diet, PPAR-γ polymorphisms (C161T), and gene-diet interactions with prostate cancer risk in Japanese men. METHODS Samples were obtained from 110 newly diagnosed prostate cancer cases and 214 biopsy-negative controls. Daily consumption of energy and macronutrients was compared between cases and controls. We used logistic regression analysis to estimate the odds ratio (OR) and 95% confidence interval (CI) for prostate cancer risk according to the genotype of the C161T polymorphism. Interactions between low/high nutrient intakes and the PPAR-γ gene polymorphism in prostate cancer risk were proved. RESULTS The daily intake of energy and macronutrients was not different between cases and controls. The C161T substitution was associated with reduced prostate cancer risk. T allele carriers of C161T showed a protective effect (multiple-adjusted OR, 0.53; 95% CI, 0.31-0.93) against prostate cancer. Among the low fat and carbohydrate intake groups, T allele carriers of C161T had reduced prostate cancer risk (multiple-adjusted OR [95% CI], 0.33 [0.13-0.83] and 0.42 [0.18-0.97], respectively); however, there were no interactions between the consumption of nutrients and PPAR-α gene polymorphisms in prostate cancer risk. CONCLUSIONS Prostate cancer can arise from interactions between high fat consumption and gene polymorphisms influencing lipid metabolism, such as in the PPAR-γ gene. PPAR-γ gene C161T substitution was associated with decreased prostate cancer risk in Japanese men. Low intake of fat or carbohydrate may strengthen the risk reduction by C161T substitution. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e89-e90 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ryosuke Ando Nagoya, Japan More articles by this author Teruo Nagaya Nagoya, Japan More articles by this author Sadao Suzuki Nagoya, Japan More articles by this author Toshiki Etani Nagoya, Japan More articles by this author Taku Naiki Nagoya, Japan More articles by this author Noriyasu Kawai Nagoya, Japan More articles by this author Keiichi Tozawa Nagoya, Japan More articles by this author Shinkan Tokudome Tokyo, Japan More articles by this author Kenjiro Kohri Nagoya, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...