Abstract
The protective association between parity and breast cancer appears to be stronger in women with sons compared to daughters. The underlying mechanism is unknown and has been hypothesized to be immunologic or endocrinologic. During pregnancy, transplacental cellular exchange results in microchimerism (Mc). Mc can persist and is associated with protection from breast cancer. We sought to evaluate whether fetal Mc concentration varies according to fetal gender, thereby potentially contributing to the differential protection of parity with sons versus daughters.
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