2173 NEAR INFRARED SPECTROSCOPY: A NOVEL NONINVASIVE DIAGNOSTIC METHOD FOR DETRUSOR OVERACTIVITY IN PATIENTS WITH OVERACTIVE BLADDER SYMPTOMS

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Urodynamic Testing1 Apr 20112173 NEAR INFRARED SPECTROSCOPY: A NOVEL NONINVASIVE DIAGNOSTIC METHOD FOR DETRUSOR OVERACTIVITY IN PATIENTS WITH OVERACTIVE BLADDER SYMPTOMS Fawzy Farag, Frank Martens, Kathleen D'Hauwers, Wout Feitz, and John Heesakkers Fawzy FaragFawzy Farag Nijmegen, Netherlands More articles by this author , Frank MartensFrank Martens Nijmegen, Netherlands More articles by this author , Kathleen D'HauwersKathleen D'Hauwers Nijmegen, Netherlands More articles by this author , Wout FeitzWout Feitz Nijmegen, Netherlands More articles by this author , and John HeesakkersJohn Heesakkers Nijmegen, Netherlands More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2410AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Near infrared spectroscopy (NIRS) is an optical technology. It detects the haemodynamic changes in biological tissues via noninvasive measurement of changes in the concentration of tissue chromophores such as oxyhaemoglobin (O2Hb) and deoxyhaemoglobin (HHb). To address the accuracy and reproducibility of NIRS to detect the haemodynamic effects of Detrusor Overactivity (DO). METHODS Forty one patients with overactive bladder (OAB) symptoms underwent one or more filling cystometries with simultaneous, trans-cutaneous NIRS of the bladder. Figure 1 shows an example of DO as detected by cystometry and NIRS. The separated graphs representing both tests were presented to 3 urodynamicists with 3 weeks between the first and second presentation. The graphs showed curves with and without DO episodes with the bladder sensations marked. The urodynamicists marked pressure changes suggestive of DO in the cystometry curves. For NIRS curves they marked definite deviations from baseline. Analysis was done to determine the sensitivity and specificity of NIRS for DO. Fleiss and Cohen's Kappa statistics were used to estimate the inter- and intra-observer agreements respectively. RESULTS The sensitivity and specificity of Hbsum (O2Hb + HHb) curves for DO were 62–97% and 62–79% respectively (AUC 0.80–0.82; p<0.001). O2Hb curves had 79–85% sensitivity and 82–91% specificity for DO (AUC 0.80–0.85; p<0.001). The sensitivity and specificity of HHb curves were 71–82% & 77–82%, respectively (AUC 0.73–0.84; p<0.001). The inter- and intra-observer agreements to trace the effect of DO on NIRS curves were substantial (Kappa >0.6). CONCLUSIONS NIRS is a potential noninvasive diagnostic method to detect DO. Its value to study the pathophysiology and treatment results in OAB syndrome will be tested. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e870-e871 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Fawzy Farag Nijmegen, Netherlands More articles by this author Frank Martens Nijmegen, Netherlands More articles by this author Kathleen D'Hauwers Nijmegen, Netherlands More articles by this author Wout Feitz Nijmegen, Netherlands More articles by this author John Heesakkers Nijmegen, Netherlands More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...