2170 β3-ADRENOCEPTOR HAVE THE ROLE FOR BLADDER SENSATION? ANALYSIS OF THE RELATIONSHIP BETWEEN β3-ADRENOCEPTOR MRNA EXPRESSION IN BLADDER MUCOSA AND URODYNAMIC FINDINGS OR DETRUSOR OVERACTIVITY

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Urodynamic Testing1 Apr 20112170 β3-ADRENOCEPTOR HAVE THE ROLE FOR BLADDER SENSATION? ANALYSIS OF THE RELATIONSHIP BETWEEN β3-ADRENOCEPTOR MRNA EXPRESSION IN BLADDER MUCOSA AND URODYNAMIC FINDINGS OR DETRUSOR OVERACTIVITY Yoshiki Kurizaki, Osamu Ishizuka, Tetsuya Imamura, Osamu Nishizawa, and Karl-Erik Andersson Yoshiki KurizakiYoshiki Kurizaki Matsumoto, Japan More articles by this author , Osamu IshizukaOsamu Ishizuka Matsumoto, Japan More articles by this author , Tetsuya ImamuraTetsuya Imamura Matsumoto, Japan More articles by this author , Osamu NishizawaOsamu Nishizawa Matsumoto, Japan More articles by this author , and Karl-Erik AnderssonKarl-Erik Andersson Winston Salem, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2407AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To investigate the possible relationship between the bladder mucosal expression of β3-adrenoceptor (AR) mRNAs, storage symptoms and urodynamic findings in patients with lower urinary symptoms (LUTS) and benign prostatic obstruction (BPO). METHODS Mucosa was obtained from the posterior bladder wall from thirty-two patients with a diagnosis of LUTS and BPO undergoing prostatectomy. β3-AR messenger RNA was quantified using competitive real-time RT-PCR. A pre-operative video urodynamic study measured volumes for first desire to void (FDV), strong desire to void (SDV) and detrusor oveactivity. Firstly, patients were divided into Group 1 with volumes for FDV ≤ 200 ml or SDV ≤ 300 ml (n = 19) and Group 2 with volumes FDV ≥ 201 ml and SDV ≥ 301 ml (n = 13). Secondly, Group 3 with positive detrusor overactivity (DO +, n = 11) and Group 4 with negative detrusor overactivity (DO -, n = 21). Thirdly, Group 5 with bladder outlet obstruction (BOO) and without acontractile detrusor (n =15), and Group 6 with no BOO (n =15). Pre-operative overactive bladder symptom score (OABSS) and international prostate symptom score (IPSS) were also evaluated. RESULTS The Group 1 FDV: 140.64 ± 11.09 ml, was significantly less than that of Group 2: 265.50 ± 25.00 ml (p = 0.00036). Similarly, the SDV for Group 1: 220.21 ± 16.06 ml was also significantly less than Group 2: 382.94 ± 20.43 ml (p = 0.00007). There were no significant differences between Groups 1 and 2 with respect to mucosal β3-AR mRNA levels. Between the Group 3 patients, DO + and the Group 4 patients, DO -, there were no significant differences in the expression level of β3-AR mRNA in the bladder mucosa. Between the Group 5 and the Group 6, β3-AR mRNA expressed more significantly in the Group 6 with no BOO (p = 0.0449) (Fig.). There was no relationship between the expression level of β3-AR mRNA in the bladder mucosa and pre-operative OABSS and IPSS. CONCLUSIONS There was no relationship between the expression of β3-AR mRNA in the bladder mucosa and bladder capacity, and the existence of detrusor overactivity measured during urodynamic study. Increase of expression of β3-AR mRNA of the BOO group awaits further investigations. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e869 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yoshiki Kurizaki Matsumoto, Japan More articles by this author Osamu Ishizuka Matsumoto, Japan More articles by this author Tetsuya Imamura Matsumoto, Japan More articles by this author Osamu Nishizawa Matsumoto, Japan More articles by this author Karl-Erik Andersson Winston Salem, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...