Abstract
Abnormalities of the permeability barrier and impaired epidermal differentiation characterize both psoriasis and atopic dermatitis, which are driven by immune responses mediated by Th1 and Th2 cytokines. The spectrum of interference of the Th1 and Th2 type cytokines with normal terminal differentiation of keratinocytes is not fully characterized. Our aim was to identify specific and common features of epidermal perturbation associated with each group of cytokines. Immortalized human keratinocytes (Ker-CT) were treated with Th1 and Th2 cytokines in pro-differentiative culture conditions with high calcium concentration.
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