2153 METABOLIC ABNORMALITIES OF UROLITHIASIS PATIENTS WITH 25-HYDROXY VITAMIN- D DEFICIENCY

Abstract

You have accessJournal of UrologyStone Disease: Basic Research1 Apr 20112153 METABOLIC ABNORMALITIES OF UROLITHIASIS PATIENTS WITH 25-HYDROXY VITAMIN- D DEFICIENCY Mohamed Elkoushy, Ramsey Sabbagh, Bernard Unikowsky, and Sero Andonian Mohamed ElkoushyMohamed Elkoushy Montreal, Canada More articles by this author , Ramsey SabbaghRamsey Sabbagh Montreal, Canada More articles by this author , Bernard UnikowskyBernard Unikowsky Montreal, Canada More articles by this author , and Sero AndonianSero Andonian Montreal, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2364AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Vitamin D deficiency and replacement has risen in popularity in recent years. However, there is no data characterizing the metabolic abnormalities in vitamin D deficient patients presenting with urolithiasis. The aim of this work was to determine urinary and serum abnormalities in patients presenting with urolithiasis and found to have 25-hydroxy vitamin D deficiency. METHODS A retrospective review of our prospectively collected data was performed to identify patients with 25, hydroxy vitamin D (VD) deficiency from August, 2009 to Jan, 2010. Patients with VD < 74 nmol/L were included and their demographic, medical and surgical data were recorded. Metabolic stone workup including 24-hours urine collection, serum calcium, PTH, TSH, and uric acid were performed. RESULTS Sixty-nine patients were included in the study of whom 37 (53.6%) were males with a mean age of 50.4±15.8 years (range: 14–87) and a mean BMI of 27.4± 6.6. Fifty-one percent had past history of urolithiasis and 54.1% had family history of stone disease. Secondary hyperparathyroidism was detected in 25.3% of these patients. Normalized ionized calcium was low in 36.2% of patients. Hyperuricemia was found in 11% of patients. Ninety-three percent of the 24-hours urine collections had at least one abnormality. The most prevalent patterns of urinary abnormalities in decreasing frequency were suboptimal urine volume (<2 L/day) in 45%, hypocitaturia in 24%, hypercalciuria in 20%, hyperuricosuria in 16%, cystinuria in 5%, and hyper-oxaluria in 3% of patients. Interestingly, 33% of patients had hypocalciuria. CONCLUSIONS Patients with 25- hydroxy VD deficiency have high incidence of abnormalities on metabolic stone workup. The relationship between vitamin D deficiency and these findings needs to be further evaluated. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e862 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mohamed Elkoushy Montreal, Canada More articles by this author Ramsey Sabbagh Montreal, Canada More articles by this author Bernard Unikowsky Montreal, Canada More articles by this author Sero Andonian Montreal, Canada More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...