215-LB: Comparison of Clinical and Serological Features among Type III APS, Isolated T1DM, and LADY/LADA

Abstract

Type III autoimmune polyendocrine syndromes (APS) is characterized by the coexistence of autoimmune thyroid disease (AITD) and T1DM. There is a rare series of studies on APS in Chinese population. This paper retrospectively analyzed the clinical and serological features of Chinese patients with type III APS who admitted to our center from Sept 2018 to Oct 2022, and compared the similarities and differences with isolated T1DM, LADY/LADA patients at the same time. The study included 69 patients, 18 patients with type III APS, 20 patients with T1DM, and 31 patients with LADY/LADA. Type III APS was predominantly female, while T1DM and LADY/LADA groups were the opposite (72.22% vs 35.00% vs 38.71%, P = 0.037). The median age of onset of diabetes in the three groups was 30.50, 23.00 and 41.00 years, respectively (P < 0.001). Hashimoto's thyroiditis (HT) (n=13, 72.22%) was the main AITD in type III APS group, followed by Graves’ disease (Table 1). The median of GADAb in the three groups were 1501.43, 115.01 and 301.02 U/mL, respectively (P = 0.022). And the levels of TPOAb and TGAb in type III APS group were significantly higher than those in the other two groups (P <0.05). Type III APS is more common in women with diabetes onset later than those with isolated T1DM and earlier than those with LADY/LADA. HT is the main AITD in type III APS patients, and the levels of GADAb and thyroid autoantibodies in patients with type III APS are often higher. Disclosure Y. Qiu: None. J. Guo: None. P. Wei: None. H. He: None. M. Jin: None. H. Zhao: None. H. Li: None. Q. Li: None.