2148 METABOLIC SYNDROME, URINE PH, AND TIME-DEPENDENT RISK OF NEPHROLITHIASIS IN KOREAN MEN WITHOUT HYPERTENSION AND DIABETES

Abstract

You have accessJournal of UrologyStone Disease: Basic Research1 Apr 20112148 METABOLIC SYNDROME, URINE PH, AND TIME-DEPENDENT RISK OF NEPHROLITHIASIS IN KOREAN MEN WITHOUT HYPERTENSION AND DIABETES Seung Hyun Ahn, Yong Taec Lee, Dong Min Lee, In Ho Chang, Tae-Hyoung Kim, Soon Chul Myung, and Young Sun Kim Seung Hyun AhnSeung Hyun Ahn Seoul, Korea, Republic of More articles by this author , Yong Taec LeeYong Taec Lee Seoul, Korea, Republic of More articles by this author , Dong Min LeeDong Min Lee Seoul, Korea, Republic of More articles by this author , In Ho ChangIn Ho Chang Seoul, Korea, Republic of More articles by this author , Tae-Hyoung KimTae-Hyoung Kim Seoul, Korea, Republic of More articles by this author , Soon Chul MyungSoon Chul Myung Seoul, Korea, Republic of More articles by this author , and Young Sun KimYoung Sun Kim Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2359AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The effect of baseline metabolic syndrome (MS) on the subsequent development of nephrolithiasis (NL) was studied, although MS status may vary over time. No previous study has examined the time-dependent association between MS and incident NL.The objective of our study was to examine the independent effect of MS on NL even with changes in MS status over time, and to investigate the mechanism of NL development in men with MS in nonhypertensive and nondiabetic men. METHODS From 2002 to 2003, 3,872 men, who were reexamined at the same hospital annually or biannually until 2009, were enrolled in the analysis and observed for development of NL. Average follow-up time was 5.77 ¡¾ 1.32 years. The examination included anthropometric measurements, biochemical measurement, and kidney ultrasonography (US).NL was evaluated by kidney US. A standard Cox proportional hazards model and a time-dependent Cox model were used to calculate the adjusted hazard ratio (HR) in the NL model. RESULTS Out of all the participants, 615 (15.9%) had MS at baseline. During follow-up, 118 incident cases of NL developed according to kidney US. After adjusted for age, baseline glomerular filtration rate, and uric acid level, MS at baseline was associated with a significantly increased risk of NL (HR, 1.771; 95% confidence interval [CI], 1.157 to 2.711). During follow-up, 801 participants developed incident MS. MS over time as a time-dependent variable also predicted the development of NL (HR, 1.678; 95% CI, 1.151 to 2.447) after adjusted baseline covariate, incidental hypertension, and incidental diabetes. After adjustment for potential confounding factors, there was a significant stepwise increase in risk of NL, with each additional MS trait compared to those with no traits of MS at baseline and follow-up. As the numbers of MS traits at baseline and follow-up increased, the urine pH of participants at baseline and follow-up decreased significantly (p <0.01). The prevalence of NL in participants with continual MS (6.6%) was higher than those with resolved MS which were similar with participants without MS, and continual MS was independent factor to predict NL on multivariate analysis. CONCLUSIONS The finding of in this study strongly suggested that MS is significantly associated with increased risk of developing by urine acidification, even with changes in status of MS observed over time during follow-up. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e860 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Seung Hyun Ahn Seoul, Korea, Republic of More articles by this author Yong Taec Lee Seoul, Korea, Republic of More articles by this author Dong Min Lee Seoul, Korea, Republic of More articles by this author In Ho Chang Seoul, Korea, Republic of More articles by this author Tae-Hyoung Kim Seoul, Korea, Republic of More articles by this author Soon Chul Myung Seoul, Korea, Republic of More articles by this author Young Sun Kim Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...