214-POS

Abstract

Objectives To determine the characteristic of inflammatory markers, programmed cell death as well as nutritional profile and its correlation in preeclampsia patients. Methods We evaluate 51 pregnant women who came to Emergency Department, Cipto Mangunkusumo Hospital in Jakarta, Indonesia on November 2011. Inflammatory marker was assessed by high sensitive C-Reactive Protein (hsCRP) and uric acid, while programmed cell death was assessed by lactate dehydrogenase (LDH) and transforming growth factor β1 (TGFβ1) as one of necrotic and apoptotic marker. Nutritional profile was marked by level of vitamin A, vitamin D3, albumin and ferritin. Preeclampsia was marked by level of angiogenic factors soluble tyrosine kinase receptor-1 (sFlt-1) and soluble Endoglin (sEng). Results The data was not normally distributed and presented in median level and Spearman Correlation. The median level of angiogenic factors were sFlt-1 17276 (10012–46578) and sEng 32183.39 (20898.53–58131.86). The median level of inflammatory markers were hsCRP 6.7 mg/dl (0.4–145.1), uric acid 5.8 mg/dl (3.4–12.8) while necrotic and apoptotic factors were LDH 396 U/L (250–2094), TGFβ1 9.36 × 10E+7. The level of vitamin A was 0.05 mg/L (0.86–0.948), vitamin D3 20 μg/L (2.8–39.8), albumin 3.5 g/dl (2.0–4.5) and ferritin 44.29 ng/ml (5.03–3105). There was medium correlation between sFlt-1 and TGFβ-1 ( r = 0.487, p r = 0.317, p = 0.023) while correlation between sFlt-1 and hsCRP and LDH were week as well as sEng and hsCRP and LDH. There was no statistically significant correlation between angiogenic factor and nutritional profile in this case. Conclusions The increasing level of angiogenic factors correlate to apoptotic and necrotic marker. It shows that cell death material secreted to maternal circulation contributed in inflammatory reaction and vasoconstriction in preeclampsia. However, nutritional profile shows no statistically significant correlation with angiogenic factors; further investigation is needed. Disclosures M. Hutabarat: None. N. Wibowo: None.