2135 REAL TIME TISSUE IMAGING BY ELASTOGRAPHY IN PATIENTS WITH NEGATIVE BIOPSY AND RISING PSA

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening1 Apr 20112135 REAL TIME TISSUE IMAGING BY ELASTOGRAPHY IN PATIENTS WITH NEGATIVE BIOPSY AND RISING PSA Lukas Manka, Tomasz Deja, Ansgar Dellmann, Marcin Slojewski, and Peter Hammerer Lukas MankaLukas Manka Braunschweig, Germany More articles by this author , Tomasz DejaTomasz Deja Braunschweig, Germany More articles by this author , Ansgar DellmannAnsgar Dellmann Braunschweig, Germany More articles by this author , Marcin SlojewskiMarcin Slojewski Szczecin, Poland More articles by this author , and Peter HammererPeter Hammerer Braunschweig, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2332AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Elastography is a novel technique for evaluation of tissue stiffness. Many studies have shown an advantage of elastography guided biopsy for detection of prostate cancer in the first biopsy. We have evaluated the feasibility and usefulness of real time elastography guided biopsy of the prostate in patients with previous negative biopsies and rising PSA. METHODS Real time elastography was performed among 85 patients with a mean age of 63,24 years with previous negative biopsies and rising PSA using an EUB 6500 and Preirus Hitachi ultrasound system (Hitachi Medical, Tokyo, Japan). 43 of 85 patients had one previous negative biopsy, 42 patients had two or more previous negative biopsies. The median PSA value was 9,74 ng/dl (ranging from 1,8 ng/dl- 36,98 ng/dl) and the median prostate volume was 55 ccm (ranging from 25-160 ccm). All patients with positive elastography findings underwent targeted prostate biopsies with a maximum of three cores followed by a 12-core systematic biopsy. RESULTS Among 85 patients prostate cancer was detected in 32 patients (38,1%). Elastography detected cancer in 29 of 32 patients (91%). The prostate cancer detection rate among 43 patient with one previous negative biopsy was 44,2% (19 patients). The detection rate among patients with two or more previous biopsies was 23,8 % (10 patients), respectively. The diagnostic sensitivity of elastography was 90,6 % with a specificity of 70 %. CONCLUSIONS Real time elastography allows a detection of prostate cancer in men with previous negative biopsies and was superior to a 12-core systematic biopsy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e854 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lukas Manka Braunschweig, Germany More articles by this author Tomasz Deja Braunschweig, Germany More articles by this author Ansgar Dellmann Braunschweig, Germany More articles by this author Marcin Slojewski Szczecin, Poland More articles by this author Peter Hammerer Braunschweig, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...