Abstract
2131 The dual contrast mechanism in inversion recovery with on-resonant water suppression magnetic resonance angiography (IRON-MRA) after administration of iron oxide nanoparticles
Highlights
After administration of a paramagnetic contrast agent, the resonance frequency of the vessels shifts in a geometrydependent way. This frequency change has recently been exploited for angiographic contrast generation ('ORCA') by Edelman [1]. This contrast enhancement was shown to depend on the angle Θ of the vessel relative to the magnetic field
It is hypothesized that IRON-MRA is less dependent on Θ, because only a narrow band in the frequency domain is attenuated, and because concomitant T1-lowering by the contrast is exploited
To study the effect of Θ in vitro, a rod-shaped phantom with 1.6 mM MION-47 in rabbit blood was placed at different angles to the field
Summary
After administration of a paramagnetic contrast agent, the resonance frequency of the vessels shifts in a geometrydependent way This frequency change has recently been exploited for angiographic contrast generation ('ORCA') by Edelman [1]. It is hypothesized that IRON-MRA is less dependent on Θ, because only a narrow band in the frequency domain is attenuated, and because concomitant T1-lowering by the contrast is exploited. To address this hypothesis, the relative contribution of off-resonance and T1-lowering to the contrast enhancement in IRON-MRA was investigated in vitro and in vivo at 3 T
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