2127 THE INCIDENCE OF DELAYED GRAFT FUNCTION IN SHIPPED LIVE DONOR KIDNEYS AND COMPARISON TO AN AGE MATCHED COHORT OF NON-SHIPPED KIDNEYS

Abstract

You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation, Renal Vascular Surgery1 Apr 20132127 THE INCIDENCE OF DELAYED GRAFT FUNCTION IN SHIPPED LIVE DONOR KIDNEYS AND COMPARISON TO AN AGE MATCHED COHORT OF NON-SHIPPED KIDNEYS Eric Miller, Eric Treat, Albin Gritsch, Suzanne McGuire, Gerald Lipshutz, and Jeffrey Veale Eric MillerEric Miller Los Angeles, CA More articles by this author , Eric TreatEric Treat Los Angeles, CA More articles by this author , Albin GritschAlbin Gritsch Los Angeles, CA More articles by this author , Suzanne McGuireSuzanne McGuire Los Angeles, CA More articles by this author , Gerald LipshutzGerald Lipshutz Los Angeles, CA More articles by this author , and Jeffrey VealeJeffrey Veale Los Angeles, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2036AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The great disparity between kidney transplant candidates and actual transplant recipients necessitates imaginative, safe and resourceful ways to provide organs to those in need. To help overcome this gap, in 2008, our institution transplanted its first shipped kidney from a living donor. This allowed for the living donor and matched recipient to undergo their procedures in a more familiar environment. With prolonged cold ischemia times (CIT) and the potential for decreased graft function, the outcome of this practice requires an in-depth analysis. The objective of this study is to examine the incidence of delayed graft function in the shipped kidney cohort and then compare these findings to the outcomes of non-shipped kidneys, both from living donors. METHODS Prospective cohort clinical study reporting immediate and intermediate outcomes for shipped living donor kidney transplants, as well as for age matched non-shipped living donor kidney transplants. RESULTS At our institution, 25-shipped kidneys have been transported using OPO networks and commercial airlines. The median shipping distance was 1,862 miles. The shipped kidneys were subsequently transplanted with a mean CIT of 11.8 ± 2.7 hours. In the shipped kidney cohort, the incidence of delayed graft function was 4.0%, coinciding well with the reported national rate for living donor transplants of 4.0% (U.S. OPTN, 2010). The incidence of delayed graft function in the matched non-shipped kidney cohort was 0%. The overall graft function for the shipped kidney cohort is currently 100%. In the immediate post-operative period, the mean rate of creatinine decrease for the shipped kidney cohort was 0.0298 mg/dL/hour, comparable to a rate of 0.0388 mg/dL/hour in the non-shipped kidney cohort. CONCLUSIONS Shipped kidneys from living donors appear to be similar to non-shipped kidneys in regards to delayed graft function and despite prolonged CIT. Early indicators of graft function, such as the mean rate of creatinine decrease, are similar when compared between shipped kidneys and an age matched cohort of non-shipped kidneys. Utilization of commercial airlines and OPO networks has proven to be cost effective and safe. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e871 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Eric Miller Los Angeles, CA More articles by this author Eric Treat Los Angeles, CA More articles by this author Albin Gritsch Los Angeles, CA More articles by this author Suzanne McGuire Los Angeles, CA More articles by this author Gerald Lipshutz Los Angeles, CA More articles by this author Jeffrey Veale Los Angeles, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...