Abstract
To study recovery of the pulmonary vasculature after cessation of positive end-expiratory pressure(PEEP) in the intact, infant lamb, electromagnetic flow probes were placed about R and L pulmonary arteries(PA) and the L atrium(LA) was catheterized through a L thoracotomy. 1 wk later, under chloralose, probe terminals and LA catheters were exteriorized. A custom-made endobronchial tube was inserted, and R and L lungs were subjected to independent, volume regulated ventilation. In each study, PEEP (11mmHg) was applied for 4 minutes to the L lung only. Aortic(Ao), PA and LA pressures, left lung peak airway pressure(Lpmax), and R and L lung blood flows(QR,QL) were recorded during and for 4 minutes after abrupt cessation of PEEP. Data was complete in 18 trials among 6 preparations. Cessation of unilateral PEEP did not measurably alter Ao pressure or cardiac output(CO). PA and LA pressures and Lpmax recovered completely within 10 seconds of cessation of PEEP. QL, however, recovered more slowly and remained depressed for at least 2 minutes (p<.01). PEEP has an effect on pulmonary vascular tone that persists after airway pressure returns to baseline.
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