211-LB: Risk of Type 2 Diabetes in Young Adults with Psychiatric Disorders

Abstract

Objective: The study of the association between type 2 diabetes (T2D) and psychiatric disorders can provide significant implications for the early detection and timely intervention of T2D. As T2D is increasingly prevalent in young adults, we explores whether young adults with psychiatric disorders have higher risk of developing T2D than those without the disorders. Research Design and Methods: We used the data collected by the South Korean National Health Insurance Service between 2009 and 2012. The nationwide population-based cohort study uses the sample data from 97% of South Korean population. Among 6,891,399 participants aged 20-39 year, we excluded 287,406 subjects with missing data and 146,002 subjects who had history of T2D were excluded. The five psychiatric disorders were evaluated, namely, schizophrenia, bipolar disorder, depressive disorder, anxiety disorder, and sleep disorder. The primary outcome was newly diagnosed T2D during the follow-up period of 7.59 years. Results: The cumulative incidences of T2D were significantly different between individuals with and without psychiatric disorders (log-rank test, P < .01). Incidence rates of T2D for individuals with and without a psychiatric disorder were 2.889 and 2.564 per 1,000 person-years. Individuals with a psychiatric disorder showed a higher risk of T2D than those without it (adjusted hazard ratio [aHR], 1.195: 95% CI, 1.174-1.217). The aHRs for T2D in individuals with schizophrenia, bipolar disorder, depressive disorder, anxiety disorder, and sleep disorder were 2.04 (95% CI, 1.826-2.28), 1.991 (95% CI, 1.726-2.115), 1.241 (95% CI, 1.202-1.282), 1.133 (95% CI, 1.108-1.159), and 1.308 (95% CI, 1.267-1.35), respectively. Conclusions: In this large-scale prospective cohort study of young adults, all five psychiatric disorders were significantly associated with an increased risk of developing T2D. We observed that young adults with schizophrenia and bipolar disorder have a higher risk of T2D. Disclosure M. Lee: None. H. Oh: None. O. Hong: None. K. Han: None. Funding National Research Foundation of Korea (2022R1F1A061069)