Abstract
2119 Visualization of micro-vasculature using FeCo-core/graphitic-carbon-shell nanocrystals and high-resolution 3D spiral imaging
Highlights
Non-invasive visualization of small vessel structures has been difficult due to insufficient contrast between small vessels and background tissue, and limited spatial resolution of MRI
We present a method to non-invasively visualize small vascular structures in-vivo, in live animals using novel contrast agents combined with fast, high resolution image encoding methods
The FeCo contrast agent provides several advantages for high resolution vessel imaging; strong relaxivity, relatively long circulation time compared to conventional Gd based contrast agent, and small nano-scale size
Summary
Non-invasive visualization of small vessel structures has been difficult due to insufficient contrast between small vessels and background tissue, and limited spatial resolution of MRI. We present a method to non-invasively visualize small vascular structures in-vivo, in live animals using novel contrast agents combined with fast, high resolution image encoding methods. To evaluate the use of 1) the FeCo-Core/Graphitic-Carbon-Shell nanocrystal contrast agent [1] and 2) the high resolution encoding enabled by 3D spiral acquisition and small surface coils for the visualization of microvasculature in-vivo
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