Abstract
211 MRI of coronary vessel wall injury in a swine model of coronary intervention using an eletrostatically stabilized VSOP nanoparticle
Highlights
Atherosclerosis is an inflammatory disease of the vessel wall with unstable lesions being associated with the presence of inflammatory cells, smooth muscle cell apoptosis, and the accumulation of LDL
After localization of the heart, coronary MR angiography (MRA) was performed using a steady state free precession imaging sequence. ~30 minutes post BMS753951 injection, delayed enhancement coronary wall imaging was performed with spatial resolution, slice thickness and image orientation maintained using an inversion recovery (IR) fast gradient echo technique
We demonstrate the exclusive visualization of VSOP nanoparticles in the injured coronary vessel as a black rim artifact on coronary MRA
Summary
Atherosclerosis is an inflammatory disease of the vessel wall with unstable lesions being associated with the presence of inflammatory cells, smooth muscle cell apoptosis, and the accumulation of LDL. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticles (~20 nm) have been shown to allow for imaging of plaque resident macrophages approximately >24 h post intravenous injection. Citrate coated very small iron oxide (VSOP) nanoparticles (~7 nm) have been found useful for steady state aortic and coronary MR angiography (MRA) and have been shown to accumulate in advanced aortic lesions in a rabbit model of atherosclerosis. In this study we wanted to test the hypothesis whether the combined use of an extracellular matrix specific Gd-based contrast agent (BMS753951) together with a VSOP nanoparticle would allow the exclusive visualization of the pathologically altered coronary vessel wall in an animal model of coronary intervention
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