Abstract
Extremity soft-tissue sarcomas can be very well controlled locally with treatment; however, the larger and more aggressive ones commonly fail distantly. A regimen of preoperative chemotherapy consisting of mesna, adriamycin, ifosfamide, and dacarbazine (MAID), interdigitated with radiotherapy followed by resection and postoperative chemotherapy, was designed to improve treatment outcome. Earlier data analysis had shown high rates of local and distant control with this regimen. Because some studies of adjuvant chemotherapy, however, have only shown delay in the appearance of metastatic disease, we were interested in evaluating the long-term outcome data on 48 patients treated with this regimen compared to an historical matched control population.
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