2103 ADJUVANT ALPHA-BLOCKERS AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY FOR DISTAL URETERAL STONES: DOUBLE-BLINDED RANDOMIZED STUDY COMPARING TAMSULOSIN AND DOXAZOSIN

Abstract

You have accessJournal of UrologyStone Disease: Evaluation & Medical Management (I)1 Apr 20132103 ADJUVANT ALPHA-BLOCKERS AFTER EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY FOR DISTAL URETERAL STONES: DOUBLE-BLINDED RANDOMIZED STUDY COMPARING TAMSULOSIN AND DOXAZOSIN Jose Bessa, José E. Moritz, Roberto G. Junqueira, Odival Timm, Marcelo J. Sette, Ernesto Reggio, Carlos H.S. Bellucci, and Érica M. Mengarda Jose BessaJose Bessa Feira de Santana, Brazil More articles by this author , José E. MoritzJosé E. Moritz Joinville, Brazil More articles by this author , Roberto G. JunqueiraRoberto G. Junqueira Joinville, Brazil More articles by this author , Odival TimmOdival Timm Joinville, Brazil More articles by this author , Marcelo J. SetteMarcelo J. Sette Joinville, Brazil More articles by this author , Ernesto ReggioErnesto Reggio Joinville, Brazil More articles by this author , Carlos H.S. BellucciCarlos H.S. Bellucci Joinville, Brazil More articles by this author , and Érica M. MengardaÉrica M. Mengarda Joinville, Brazil More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2012AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The present study's objective is to compare the efficacy and side effects of the adjuvant use of tamsulosin or doxazosin after extracorporeal shock wave lithotripsy (ESWL) for distal ureteral stones. METHODS We conducted a double-blinded randomized trial involving 141 patients with distal ureteral stones sonographically diagnosed. Patients were categorized into two groups. Group 1 (n=71) received daily treatment with 4mg doxazosin and group 2 (n=70) received daily 0,4mg tamsulosin after one session of ESWL. Alpha-blocker therapy was taken until fragments expulsion or for 30 days. Patients were daily evaluated clinically and sonographically. Stone free rates at 14th and 21st day after ESWL, mean days to stone elimination and side effects were compared between the groups. RESULTS Both groups were similar according to age, sex, body mass index, stone size, distance to ureterovesical junction and presence of hydronephosis. Mean stone size was 5.98 ± 1.82 mm in group 1 and 5.86 ± 2.19 mm in group 2 (p=0.705). After 14 days of ESWL, stone free rate was 70.42% in group 1 (50 of 71) and 70.00% in group 2 (49 of 70) (p=1.0). After 21 days, the rates were 73.23% and 71.42% in groups 1 e 2 respectively (p=0.563). Mean time to expulsion was 5.00 ± 3.96 days in group 1 and 5.46 ± 3.57 days in group 2 (p= 0.543). The prevalence of side effects were similar in both groups (18.3% in group 1 and 12.8% in group 2; p=0,483) and no patient discontinued therapy. CONCLUSIONS Tamsulosin and doxazosin had similar efficacy and side effects as adjuvant therapy after ESWL for distal ureteral stones. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e862 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jose Bessa Feira de Santana, Brazil More articles by this author José E. Moritz Joinville, Brazil More articles by this author Roberto G. Junqueira Joinville, Brazil More articles by this author Odival Timm Joinville, Brazil More articles by this author Marcelo J. Sette Joinville, Brazil More articles by this author Ernesto Reggio Joinville, Brazil More articles by this author Carlos H.S. Bellucci Joinville, Brazil More articles by this author Érica M. Mengarda Joinville, Brazil More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...