Abstract
The aldol reaction is one of the most powerful methods for the construction of carbon–carbon bonds in organic chemistry. Over the years, the control of the chemo-, regio-, diastereo-, and enantioselectivity of the aldol reaction has been a leading subject in synthetic organic chemistry. In recent years, considerable interest has been devoted to the development of atom-economical, catalytic methods that retain the high level of control realized previously by the classical stoichiometric approach. In the rapidly growing area of the catalytic aldol reaction, this chapter details recent advances in the transition metal catalysis, including the direct aldol reaction, the decarboxylative aldol reaction, the reductive and alkylative aldol reaction, and the tandem isomerization/aldol reaction of allylic alcohols.
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