Abstract
The ribonuclease RNase 7 (R7) is abundantly expressed in human skin and exhibits antimicrobial and immunomodulatory properties. R7 is also a potent ribonuclease and degrades host RNA. Free host RNA, which is released upon cell damage and injury, induces inflammatory mediators in keratinocytes. We hypothesized that the ribonuclease activity of R7 may modulate this RNA- mediated inflammatory response by its capability to degrade RNA. To follow this hypothesis we stimulated normal human keratinocytes (NHEK) with the RNA-analogue poly(I:C).
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