Abstract
Background: In oncology, oral mucositis (OM) is a common adverse event caused by chemotherapy as well as targeted agents. The overall incidence of OM in patients receiving chemotherapy is approximately 40%. Cryotherapy is used occasionally to prevent OM during treatment with melphalan and 5-fluorouracil. Oral cryotherapy might also limit OM in patients receiving doxorubicin, but evidence to support this is currently lacking. Therefore, the objective of the current study is to investigate if oral cryotherapy is effective for reducing the incidence of OM in patients treated with doxorubicin chemotherapy.
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