210.9: The High Incidence of Long-COVID-19 in Kidney Transplantrecipients: A Longitudinal Cohort Study

Abstract

Purpose: This study aimed to investigate the clinical consequences three months after symptom onset among kidney transplant recipients surviving COVID-19. Methods: This is an ongoing single-center observational prospective study that includes adult kidney transplant recipients diagnosed and survived after COVID-19 between 03/20/2020 and 05/31/2021. Patients who lost their graft were excluded. The patients will receive a telephone at 3, 6, and 12 months after symptom onset from the clinical research team. The call consisted of a structured symptoms questionnaire with binary answers (yes or). The questionnaire included the following symptoms: headache, dizziness, anosmia/ageusia, weakness, myalgia, inappetence, diarrhea, and dyspnea, which could be presented before and/or after the COVID-19 diagnosis. Those patients with at least one symptom showed just after the disease was defined as having Long-COVID-19. Subsequently, the clinical research team included a question about the work status. Adjusted multivariable logistic regression models were used to identify the risk factors associated with Long-COVID-19. Results: There were 1,731 patients with COVID-19, with 455 deaths and 36 graft losses. Of the remaining 1,240 patients, 454 (36%) didn’t answer our calls, yielding a final cohort of 786 patients. Of them, 217 (28%) developed Long-COVID-19. The incidence of each symptom at three months was: dyspnea (7%), myalgia (12%), weakness (11%), headache (10%), dizziness (7%), diarrhea (4%), inappetence (4%) and anosmia/ageusia (3%). About 1% of our patients needed domiciliary O2. Of those who obtained the functional status (n=239), 95 (40%) were employed before COVID-19, and 79 of them (83%) had returned to their original work at three months. After COVID-19 diagnosis, 44% of the patients were hospitalized (31% in ICU), 35% used supplemental O2, and 5% required mechanical ventilation. Fever (53%), shiver (39%), nausea (3%), anosmia/ageusia (59%), hospitalization (67%), and adverse cardiovascular events (3%), such as thrombosis or myocardial infarction, were risk factors associated with subsequent development of Long-COVID-19, using adjusted multivariable logistic regression. Conclusion: The incidence of Long-COVID-19 at three months was 28% and was associated with reduced quality of life and return to work. Several COVID-19 associated symptoms and disease severity markers were associated with Long-COVID-19.