Abstract
Human cholangiocarcinoma (CHC) is one of the most dismal biliary tree cancers to cure. We describe the effects of conventional HIA chemotherapy (FUDR) to experimental pig CHC in comparison with those by FUDR con-jugates (FUDR-CEA, FUDR-Cathepsin B). Methods In 21 male pigs (Long white landrase) -weight 23 Kg, a CHC was induced by intraportal application of aflatoxin B, and 4-methylcholantren. After the end of cancerogenesis (affected 40% of the liver in US), a regional chemotherapy (HIA) has began. Results In the FUDR group, the median survival was 86,6 days; no tumour regression was seen during the autopsy. In the FUDR-CEA group, the median survival was 139,3 days. In the course of autopsy, some reduction of the tumour mass could be observed. In the FUDR-Cathepsin B group, the results of HIA chemotherapy were quite expressive. The median survival reached 210,7 days. Autopsy revealed a significant reduction of the tumour tissue according to US. Conclusions FUDR-conjugates seems to be much more potent drugs in the pig CHC palliation as FUDR alone. The same is possible to expect in human biliary tree cancers.
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