Abstract

Some 17β-acetyl steroids have been converted into 21-hydroxy-20-ketosteroids in high yields upon treatment with phenyliodosodiacetate in methanolic potassium hydroxide. Attempts to carry out the same reaction with several 17α-acetyl steroids derivatives were unsuccessful. The structure of substrates and products was confirmed by the IR, mass spectrometry, and 1H NMR techniques.

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