Abstract
CONCLUSION An increased frequency of autoimmune diseases and an elevated incidence of autoantibodies have been observed in Turner syndrome (TS). Indirect immunofluorescence (IIF) has not been able to demonstrate autoantibodies against the adrenal cortex. We asked if the more sensitive radioimmunosorbant assay (RIA) employing recombinant human 21-hydroxylase was able to identify autoantibodies against 21-hydroxylase, (21OH-Ab) in TS patients; 21-hydroxylase is the major adrenal cortex autoantigen in patients with autoimmune Addison’s disease. Moreover, TS patients were tested for antibodies against interferon omega (IFNω-Ab), a marker for autoimmune polyendocrine syndrome 1 (APS 1) where autoimmune Addison’s disease is one of the main components along with chronic mucocutanous candidiasis and hypoparathyroidism.
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