21. ENIGMA-Relatives: The Association Between Familial Risk for Schizophrenia or Bipolar Disorder and Brain Abnormalities

Abstract

Schizophrenia and bipolar disorder share genetic liability and some structural brain abnormalities are common to both conditions. Interestingly, imaging studies have indicated that there may be a converse pattern of brain abnormalities in first-degree relatives of schizophrenia patients (FDRs-SZ) and bipolar patients (FDRs-BD), with smaller volumes reported in FDRs-SZ and enlargements in FDRs-BD.