Abstract
To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism. Patients-50 boys aged 1-4years (median=2.4years) with unilateral cryptorchidism. The control group-50 healthy, age-matched boys (aged 1-4years, median=2.1years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging. The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2years old and above 2years old. We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.
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