20P Molecular mechanism of MK2-CRABP2 signaling pathway mediating the progression of lung adenocarcinoma

Abstract

The morbidity and mortality of lung cancer rank the first among malignant tumors in China. EGFR-TKIs has achieved good efficacy in advanced lung adenocarcinoma with EGFR-positive, however, drug resistance and rapid progress of some patients are still inevitable. Therefore, it is of great significance to find new therapeutic targets. Abnormally activated transcriptional regulators are involved in many biological processes of the development of malignant tumors, further exploration of their functional mechanisms is expected to provide a new direction for targeted tumor therapy.