2091501 Liver Stiffness Values Measured By Virtual Touch ARFI In Comparison To Fibroscan TE: A Vietnamese Experience

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To compare Acoustic Radiation Force Impulse imaging (ARFI of Acuson S2000) with Transient Elastography (TE of FibroScan) for investigating whether ARFI can be a feasible and accurate technique in the assessment of liver fibrosis. We conducted the study on 586 cases at the Medic Medical Center from September 2011 to December 2012, including 369 males, 382 cases of chronic viral hepatitis and 94 healthy, age from 17 to 85yo, BMI=14.82 to 32.39. All were examined by two sonologists performing ARFI and TE techniques in the same day. Medcalc statistical software was used to compare ARFI values(V=m/sec) and TE values(F=kPa). There is close correlation between ARFI and TE techniques with statistical significance of fibrosis staging, correlative coefficient r=0.8005 with p<0.0001, 95%CI=0.7694-0.8278. The shear wave velocity means of ARFI range from 0.79 to 3.53m/sec, standard deviation from 0.01 to 1.05m/sec, 90%≤0.27m/sec, control group V=1.04±0.10m/sec and there are statistically significant differences between the phases and between the two groups V0,1,2 and V3,4 with t range from 11.74 to 27.32 (p<0.0001). Values of TE range from 2.2 to 75kPa. Close clinical agreement between FibroScan F4 and ARFI F4, kappa=0.767. With the regressive equation y=0.9532+0.04402x (where x=F kPa and y=V m/sec), we propose a fibrosis staging of ARFI as follows: F0≤1.17m/s; 1.17<F1≤1.26m/s; 1.26<F2≤1.33m/s; 1.33<F3≤1.59m/s; F4>1.59m/s. Virtual Touch ARFI has diagnostic accuracy similar with Fibroscan TE in assessing liver fibrosis in the present study of 586 cases. This technique is easy to perform and can be applicable in clinical practice.