Abstract
by renal macrophages was observed under a transmitted electron microscope (TEM). RESULTS: Experiment 1: J774.1 indicated higher COM crystal phagocytosis rate than M1 (p 0.0038). The rate increased along with the increase in exposure to the COM crystals (COM, 12.5 g/cm: 19.3 5.86%; COM, 62.5 g/cm: 39.7 5.51%). The phagocytosis rates in the CB groups were significantly lower than those in the non-CB groups (COM, 12.5 g/cm: 0.7 1.15%, p 0.0056; COM, 62.5 g/cm: 13.3 3.21%, p 0.0020). Experiment 2: The number of renal tubular crystals increased until day 6 and thereafter decreased and disappeared until day 15. Renal macrophages appeared in the interstitium, and their number increased or decreased, correlating with the amount of crystals. The TEM image demonstrated phagocytosis of the crystals by interstitial macrophages. CONCLUSIONS: Macrophages have the ability to englobe calcium oxalate crystals and thus play an active role in preventing kidney stone formation.
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