208 Long-term and seasonal impact of a vitamin D3 (cholecalciferol) supplementation protocol on vitamin D [25(OH)D] serum levels among cystic fibrosis adults in a Montreal clinic

Abstract

Vitamin D deficiency is a widely reported problem in patients with Cystic Fibrosis (CF). Objectives To analyse the long term and seasonal impact on vitamin D [25(OH)D] serum levels of our vitamin D3 protocol. Methods A retrospective study was performed in our CF adult clinic. Data for 200 patients were obtained from their medical files for 2009, and compared to their own latest data available (2013–2014). Protocol Total starting D3 prescribed dose was 2800 IU/day during the summer months (May to October), 4400 IU/day during the winter months (November to April) or the weekly dose equivalent. Results Population studied: 55% male/45% female, age 34.4±8.3 years, FEV1% 65.1±21.4, BMI 23.2±3.5 kg/m 2 , 85.5% with pancreatic insufficiency. Mean 25(OH)D serum levels were significantly superior after the protocol (64.7±25.6 nmol/L vs 92.3±28.4 nmol/L, p TableLong-term impact of D3 Protocol25(OH)D serum level adequacyProportion of patientsBefore D3 ProtocolAfter D3 ProtocolDeficient, 150 nmo1/L0.5%3% Before the protocol, patients showed significant seasonal variation in 25(OH)D serum levels with lower levels in winter months compared to summer months (58.6±28.6 nmol/L vs 69.6±21.7 nmol/L, p Conclusion This study suggests that a vitamin D3 supplementation protocol with higher doses during winter months was efficient for the long term and seasonal management of vitamin D deficiency in our Montreal adult CF clinic.