2079-P: Racial Differences in Gut Microbiota, ß-Cell Function, Body Fat Distribution, and Their Relation with Incretins in Subjects with Normal Glucose Tolerance

Abstract

Racial differences in the gut microbiota and its influence in development of diabetes have been previously reported. However, whether differences exist between Chinese and Africans, currently no study. We investigated whether differences in body fat may account for microbial communities to expound racial disparities in insulin secretion, sensitivity or resistance, and that GLP-1 may play a role. We measured fasting and stimulated GLP-1, insulin and glucose levels during a 3h OGTT in 27 Han-Chinese university students(HC) and 29 International students from East Africa(EA) healthy subjects with normal glucose tolerance. We also measured the whole body fat and the regions of interest of local body composition, and gut microbiota composition. HC group showed significantly higher triglyceride levels, total bile acids, glucose response at 30min, incremental glucose level at 30min, HOMA-IR at 30 min, body fat distribution and abundance of microbial phyla, but lower hip circumference and β-cell function than EA. Interestingly, HC had lower bacterial taxa and majority of measures of microbial diversity than EA. GLP-1 correlated with metabolic risk factors and microbial communities. The results suggest that body fats are associated with gut microbiota and that GPL-1 enhances their association, which in turn may result in Chinese developing T2DM. Disclosure P. Nizigiyimana: None. L. Liu: None. B. Xu: None. T. Liu: None. L. Gao: None. Z. Liu: None. C. Li: None. X. Luo: None. M. Lei: None.