Abstract
Objective: This study was designed to examine changes in body fat distribution after laparoscopic sleeve gastrectomy (LSG) and to confirm whether these changes are correlated with increased testosterone. Methods: A retrospective study was performed in 51 obese female patients with BMI 30-45 kg/m2 who underwent LSG from Shanghai Tenth People’s Hospital, 38 of whom were PCOS patients. The anthropometric indexes, sex hormone and ovarian volume of ultrasound examinations include both sides ovarian volume, mean ovarian volume (MOV) and maximal ovarian volume (MaxOV) were observed preoperative and follow-up at 3 and 6 months after LSG. The metabolic indexes and ovarian volume were compared before and after surgery. Results: Compared with preoperative, PCOS patients' weight, BMI, waist circumference and hip circumference were significantly lower at 3 and 6 months after operation (P<0.05). Percentage of excess body weight loss(%EWL) for 3 months and 6 months after LSG was 56.32% and 75.98%. TT and cFT showed a downward trend at 3 and 6 months after surgery while SHBG showed an upward trend (P<0.05). Both sides ovary volume and MOV, MaxOV all decreased at 6 months after LSG, but there was no statistically significant difference compared to baseline. Compared with patients without PCOS, the preoperative MOV, MaxOV, and left ovary volume were significantly larger (P<0.05). At 6 months after surgery, the MOV, MaxOV, left ovary volume and right ovarian volume of PCOS and non-PCOS patients were all reduced. The differences in MOV, MaxOV, left ovary volume and right ovarian volume were no longer statistically significant between the two groups. Conclusions: TT and cFT decreased and SHBG increased significantly after LSG. MOV shrinked at 6 months after LSG and was no longer different from non-PCOS patients. LSG is not only an important treatment for weight loss, but also improve PCOS and its clinical symptoms effectively in severe obese women. Disclosure J. Gao: None. M. Zhang: None. C. Zhu: None. X. Wang: None. F. Mei: None. S. Qu: None. Funding National Natural Science Foundation of China (81601269)
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