Abstract
The PRINS lncRNA is a differentially expressed transcript in psoriatic perilesional epidermis. We have recently shown its role in keratinocytes’ inflammatory responses by downregulating the expression of IL-6 and CCL-5 through sequence specific binding to their respective mRNAs. We aimed at identifying additional targets for PRINS-mediated regulation in inflammatory reactions of normal human epidermal keratinocytes (NHEK; n=4). Cytosolic exposure to synthetic analogues of dsDNA [poly(dA:dT)] and dsRNA [poly(I:C)] was used to model psoriasis-associated inflammatory conditions with plasmid-based overexpression or silencing of PRINS.
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