207 CLINICAL CHARACTERISTICS AND TARGET-ORGAN DAMAGE IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME

Abstract

Objective: The metabolic syndrome consists of abdominal obesity, insulin resistance, glucose intolerance, hypertension, and dyslipidemia. The prevalence of metabolic syndrome (MS) in Korea is continuously increasing. Hypertension is a component of metabolic syndrome and has intimate relations with pathophysiology and clinical importance. The aim of this study is to evaluate clinical and chemical characters in hypertensive patients with MS. Methods: We reviewed medical records of patients with hypertension in BORAMAE Medical center. Only the patients with metabolic syndrome were included. Anti-hypertension medications were classified according to their action mechanism. The prevalence of target-organ damage was evaluated, including left ventricular hypertrophy, heart failure, coronary artery disease, albuminuria, renal failure, carotid atheroma, arterial stiffness, cerebrovascular disease. Results: Of 155 patients with MS, 66% was obese, 46% had high triglyceride, 61% had low HDL-cholsterol, 62% was glucose intolerance. ACE inhibitor and angiotension II receptors blocker (ARB) were used in 86 patients, beta blocker in 34 patients, calcium channel blocker in 86 patients, diuretics in 25 patients. The prevalence of disease related with target-organ was 31, 28, 15, 16 events respectively for heart, kidney, peripheral vessels, brain. 5% of total patients showed left ventricular hypertrophy, 7% showed heart failure, 10% showed coronary artery disease. 9% of total patients showed microalbuminuria, 14% showed decrease glomerular filtation rate. Conclusion: The hypertensive patients with MS showed multiple target-organ damage and need proper management on hypertension, diabetes, dyslipidemia, obesity.ACE=Angiotensin Converting Enzyme; ARB=Angiotensin II receptor blocker; BB=Beta blocker; CCB=Calcium channel blocker