Abstract
Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H2S) by using L-cysteine (LC) as a substrate and is involved in glucose and lipid homeostasis. Irisin is a novel myokine secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (Fndc5) and can regulate glucose homeostasis. Diabetes and obesity are associated with low blood levels of Irisin, H2S, and LC. We examined the hypothesis that CSE-deficiency decreases the level of H2S, which can lead to decreased Fndc5 and thereby alter glucose metabolism. High-fat-diet-fed (16 weeks) mice exhibited elevated blood glucose, and decreased CSE, H2S, and peroxisome proliferator-activated receptor-γ-coactivator-1α (PGC-1α), with reduced Fndc5/Irisin and increased oxidative stress in the muscle (p
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