2059 COMPLICATION RATE AND POST-OPERATIVE QUALITY OF LIFE IN PATIENTS CANDIDATES FOR FOCAL THERAPY WHO UNDERWENT TEMPLATE-ASSISTED TRANS-PERINEAL PROSTATE BIOPSY

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening IV1 Apr 20122059 COMPLICATION RATE AND POST-OPERATIVE QUALITY OF LIFE IN PATIENTS CANDIDATES FOR FOCAL THERAPY WHO UNDERWENT TEMPLATE-ASSISTED TRANS-PERINEAL PROSTATE BIOPSY Andrea Losa, Giulio Maria Gadda, Massimo Lazzeri, Giovanni Lughezzani, Giuliana Lista, Alessandro Larcher, Massimo Freschi, Andrea Cestari, Nicolò Maria Buffi, Francesco Montorsi, Patrizio Rigatti, and Giorgio Guazzoni Andrea LosaAndrea Losa Milan, Italy More articles by this author , Giulio Maria GaddaGiulio Maria Gadda Milan, Italy More articles by this author , Massimo LazzeriMassimo Lazzeri Milan, Italy More articles by this author , Giovanni LughezzaniGiovanni Lughezzani Milan, Italy More articles by this author , Giuliana ListaGiuliana Lista Milan, Italy More articles by this author , Alessandro LarcherAlessandro Larcher Milan, Italy More articles by this author , Massimo FreschiMassimo Freschi Milan, Italy More articles by this author , Andrea CestariAndrea Cestari Milan, Italy More articles by this author , Nicolò Maria BuffiNicolò Maria Buffi Milan, Italy More articles by this author , Francesco MontorsiFrancesco Montorsi Milan, Italy More articles by this author , Patrizio RigattiPatrizio Rigatti Milan, Italy More articles by this author , and Giorgio GuazzoniGiorgio Guazzoni Milan, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2224AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Template biopsies (TB) appear to be a promising tool for identifying patients suitable for focal therapy (FT). The aim of our study is to assess the complication rates and quality of life (QoL) outcomes of patients who underwent TB. METHODS From September 2009 to October 2011, 75 patients eligible for FT underwent TB. Inclusion criteria were either diagnosis of low risk PCa (PSA< 10 ng/ml and Gleason score 3+3 in 1 to 3 unilateral cores) or ASAP/HG-PIN. For all patients, pre, intra and post-operative data were carefully recorded. Primary outcomes were complication rate according to the Clavien-Dindo classification and QoL before and one month after TB, evaluated using IPSS, IIEF and FACT-P questionnaires. Secondary outcomes were pathological results as reported by a single, dedicated genito-urinary pathologist. RESULTS Median age was 65 years (range 46-78) with a median Charlson Comorbidity Index of 2 (range 0-4). Median prostate volume was 48 cc (range 14-100), median number of cores was 39 (range 29-70), median number of cores per cc was 0,87 (range 0,33-2,38) and median number of positive cores was 3 (range 1-11). Primary outcomes: no statistically significant differences were observed when comparing general and/or specific domains for IPSS, IIEF and FACT-P before and one month after TB (all p-values > 0,05). According to the Clavien-Dindo classification, we observed 35 cases of grade 1 complications, namely 5 (6,6%) cases of macrohaematuria, 13 (17,3%) of haemospermia, 11 (14,6%) of perineal haematoma, 3 (4%) of perineal haematoma and haemospermia and 3 (4%) of macrohaematuria and haemospermia, and 3 (4%) grade II complications, namely acute urinary retention, which required indwelling catheter for one week. Secondary outcomes: PCa was detected in 46 patients (61,4%). Gleason score was 3+3 in 32 patients (69,6%), 3+4 in 13 (28,3%) and 4+3 in 1 patient (2,1%). Twelve patients out of 57 (21%) were upgraded from GS 3+3/ASAP to GS 7. Among 46 patients with positive TB, 24 (52,2%) patients showed an anatomical correspondence between the results of previous biopsies and TB, while 22 (47,8%) patients were diagnosed with multifocal and/or bilateral PCa. CONCLUSIONS Template-assisted trans-perineal prostate biopsy did not appear to have a significant impact on the QoL of patients candidates to FT. Furthermore, no life-threatening complication did occur and global Clavien Dindo complication rate revealed to be negligible. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e831 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Andrea Losa Milan, Italy More articles by this author Giulio Maria Gadda Milan, Italy More articles by this author Massimo Lazzeri Milan, Italy More articles by this author Giovanni Lughezzani Milan, Italy More articles by this author Giuliana Lista Milan, Italy More articles by this author Alessandro Larcher Milan, Italy More articles by this author Massimo Freschi Milan, Italy More articles by this author Andrea Cestari Milan, Italy More articles by this author Nicolò Maria Buffi Milan, Italy More articles by this author Francesco Montorsi Milan, Italy More articles by this author Patrizio Rigatti Milan, Italy More articles by this author Giorgio Guazzoni Milan, Italy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...