2052 INSULIN-LIKE GROWTH FACTOR-I (IGF-I) POLYMORPHISMS PREDICT THE SURVIVAL OF PROSTATE CANCER PATIENTS WITH BONE METASTASIS AT INITIAL PRESENTATION

Abstract

You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 20102052 INSULIN-LIKE GROWTH FACTOR-I (IGF-I) POLYMORPHISMS PREDICT THE SURVIVAL OF PROSTATE CANCER PATIENTS WITH BONE METASTASIS AT INITIAL PRESENTATION Norihiko Tsuchiya, Shintaro Narita, Zhiyong Ma, Yohei Horikawa, Hiroshi Tsuruta, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, Takamitsu Inoue, Osamu Ogawa, and Tomonori Habuchi Norihiko TsuchiyaNorihiko Tsuchiya Akita, Japan More articles by this author , Shintaro NaritaShintaro Narita Akita, Japan More articles by this author , Zhiyong MaZhiyong Ma Akita, Japan More articles by this author , Yohei HorikawaYohei Horikawa Akita, Japan More articles by this author , Hiroshi TsurutaHiroshi Tsuruta Akita, Japan More articles by this author , Kazuyuki NumakuraKazuyuki Numakura Akita, Japan More articles by this author , Mitsuru SaitoMitsuru Saito Akita, Japan More articles by this author , Shigeru SatohShigeru Satoh Akita, Japan More articles by this author , Takamitsu InoueTakamitsu Inoue Akita, Japan More articles by this author , Osamu OgawaOsamu Ogawa Kyoto, Japan More articles by this author , and Tomonori HabuchiTomonori Habuchi Akita, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2099AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The insulin-like growth factor I (IGF-I) plays an important role in androgen-independent growth of prostate cancer cells and facilitating the progression of prostate cancer particularly after hormone therapy failure. This study aimed to evaluate the predictive values of four polymorphisms in three haplotype blocks of the IGF-I gene on the survival of metastatic prostate cancer patients. METHODS A total of 213 patients with bone metastases at initial presentation were included in this study. Cytosine-adenine (CA) repeat polymorphism and rs12423791 were selected as representative polymorphisms in haplotype blocks 1 and 2, respectively. Haplotype in block 3 was analyzed using two tag single nucleotide polymorphisms (SNPs), rs7136446 and rs6220. Cancer-specific and overall survival rates were estimated from the Kaplan-Meier curve, and the survival data were compared using the log-rank test. RESULTS Cancer-specific survival was significantly associated with each polymorphism in haplotype blocks 1 and 2 of the IGF-I gene (P = 0.007 and 0.020, respectively). Although tag SNPs in block 3 alone had no significant association with survival, the expected haplotype in block 3 was significantly associated with cancer-specific survival (Fig. 1). When the patients were divided into three groups as 0 (favorable), 1–2 (intermediate), and 3 (unfavorable) based on the number of risk alleles or haplotypes, the unfavorable group showed significantly worse cancer-specific survival than the intermediate or favorable groups (P = 0.037 or 0.0002, respectively) (Fig. 2). CONCLUSIONS Polymorphisms, especially the combination of these four polymorphisms in each haplotype block of the IGF-I gene, are assumed to be novel genetic markers predicting the outcome of metastatic prostate cancer. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e797-e798 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Norihiko Tsuchiya Akita, Japan More articles by this author Shintaro Narita Akita, Japan More articles by this author Zhiyong Ma Akita, Japan More articles by this author Yohei Horikawa Akita, Japan More articles by this author Hiroshi Tsuruta Akita, Japan More articles by this author Kazuyuki Numakura Akita, Japan More articles by this author Mitsuru Saito Akita, Japan More articles by this author Shigeru Satoh Akita, Japan More articles by this author Takamitsu Inoue Akita, Japan More articles by this author Osamu Ogawa Kyoto, Japan More articles by this author Tomonori Habuchi Akita, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...