Abstract
2045 Dichotomization of lvh regression and diastolic function in severe pressure overload hypertrophy
Highlights
Elegant invasive human and animal studies from the University of Zurich and the Medical University of South Carolina have shown that in subjects with pressure overload due to severe aortic stenosis (AS), following aortic valve replacement (AVR), while myocyte regression is relatively rapid, the interstitial collagen content regression lags. This manifests as a blunted improvement in diastolic function as assessed by cardiac MRI when related to LVH regression over time after AVR for AS
E:A ratios and/or morphology almost always uniformly improved (9/10 patients; 90%) from 0.9:1 to 1.7:1 (p < 0.005) accounting for 4 patients improving one complete diastolic function stage
Using predictive modeling from historic data, the improvement seen in diastolic function as related to improvements in LV mass regression was incomplete and tardy
Summary
Elegant invasive human and animal studies from the University of Zurich and the Medical University of South Carolina have shown that in subjects with pressure overload due to severe aortic stenosis (AS), following aortic valve replacement (AVR), while myocyte regression is relatively rapid, the interstitial collagen content regression lags.
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