Abstract
Background: The positive effect of azithromycin (AZM) on lung function in Cystic Fibrosis (CF) patients have been showed by many clinical trials, but studies were less long than 1 year. Aim: To evaluate the effect of a long course of low dose AZM on lung function in CF patients. Subjects and Methods: 43 patients (26 F) with chronic infection by Pseudomonas aeruginosa (PA), age ranged between 6 and 39 years (mean ±SD: 17.8±7.4 years) had a AZM (250mg/day) 3-years treatment. In all patients FVC, FEV1, FEF 25−75, expressed as percentage of predicted, and SpO2 (%), were measured at 3 month intervals and were compared with the corresponding values recorded at 3 month intervals during 3 years before starting AZM treatment. Linear regression analysis was used and a p value <0.05 was considered as significant. Results: The change in lung function and oxygen saturation observed during the 3 years before starting AZM treatment was significantly different from that during the 3 years, when patients were treated (table).
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