2035 FAMILY HISTORY OF PROSTATE CANCER DOES NOT INCREASE THE RISK OF DETECTION OF PROSTATE CANCER NOR HIGH GRADE DISEASE IN MEN UNDERGOING INITIAL PROSTATE BIOPSY

Abstract

in men with prostate cancer (CaP). Although there is debate, many studies have found association between these CaP risk alleles and aggressive pathology features in the radical prostatectomy specimen. The objective of the present study was to evaluate the relationship between CaP risk alleles and Gleason up-grading. METHODS: The genotypes of 17 previously reported CaP susceptibility alleles on chromosomes 2p15, 3q21, 5p15, 8q24, 10q11, 11q13, 17q12, 17q24, 19q13, and Xp11 were determined for 900 men of European ancestry (Caucasian) who underwent radical prostatectomy. All patients had a biopsy Gleason grade of 6. For the purposes of these analyses, the “up-graded” group increased to a pathologic Gleason score 7 and the “control” group had a final pathologic Gleason score of 6. The frequencies of the CaP risk alleles were calculated for each group. RESULTS: Table 1 compares the allele frequency for men in the “up-graded” and “control” groups. Alleles on chromosome 8q24 and 19q13 were significantly over-represented in men who were up-graded. Multivariate analyses adjusting for carrier status, age, and PSA show that men who were carriers of chromosome 8q24 and 19q13 were 1.7 and 2.7 times more likely to be up-graded in the final pathology specimen, respectively. CONCLUSIONS: Prior studies have reported an association between many of the CaP risk alleles and aggressive pathology features. Our study demonstrates that several of these alleles may predict the presence of higher Gleason grade disease in the prostatectomy specimen. Larger prospective studies are warranted to further examine whether these genotypes can predict up-grading in other populations of men.