2022 DOES TOPICAL TRANEXAMIC ACID REDUCE POST TURP HEMATURIA; A DOUBLE BLIND RANDOMIZED CONTROL TRIAL

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy and New Technology II1 Apr 20122022 DOES TOPICAL TRANEXAMIC ACID REDUCE POST TURP HEMATURIA; A DOUBLE BLIND RANDOMIZED CONTROL TRIAL Aziz Abdullah and Atif Javed Aziz AbdullahAziz Abdullah Karachi, Pakistan More articles by this author and Atif JavedAtif Javed Karachi, Pakistan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2185AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Transurethral resection of prostate (TURP) is considered to be the gold standard treatment of BPH. Bleeding after TURP is most common complication. To reduce post operative hematuria several different approaches have been tried. Tranexamic acid prevents bleeding by inhibiting TPA. Recent studies have proven the role of topical application of tranexamic acid in reducing the blood loss after orthopedic and dental surgeries. However role of topical application of tranexamic acid in decreasing hematuria after TURP through irrigation fluid has not been studied. OBJECTIVES: To evaluate the role of topical application of tranexamic acid through irrigation fluid in reducing post TURP hematuria. METHODS A double blind randoized control trial in which fifty two men who underwent TURP and met inclusion crieteria were randomised to receive irrigation fluid with 500 mg tranexamic acid in one litre normal saline and placebo. Weight of resected prostate, intra-operative blood loss and blood loss on 1st and 2nd post operative day were measured and difference between two groups were calculated. RESULTS Both groups (which received tranexamic acid vs placebo) were comparable in terms of mean prostatic weight (58.84gm vs 56.15gm), mean resected prostate (31.92gm vs 32.30gm) and mean duration of resection (36.53 vs 31.46). Patients who received tranexamic acid in irrigation fluid had slightly decreased drop in mean hemoglobin levels (0.87gm on 1st P.O.D and 0.31gm on 2nd P.O.D) as compared to the patients who received placebo in irrigation fluid (0.98gm on 1st P.O.D and 0.95gm on 2nd P.O.D). CONCLUSIONS Topical tranexamic acid through irrigation fluid decreases blood loss after TURP. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e816 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aziz Abdullah Karachi, Pakistan More articles by this author Atif Javed Karachi, Pakistan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...