Abstract
The IgNITE Medical Case Competition is an annual research case competition organized by students at the University of Ottawa. Our mission is to provide high school and university students the opportunity to gain valuable research experience while networking with industry professionals. Each year students, in teams of 1-4, are paired with an experienced mentor to develop and present a novel research proposal within the specified theme of the competition. During the competition, students are taught the fundamental principles underlying three lab techniques which they can then use in their proposal or their future research career. This year’s theme was Regenerative Medicine and competitors learned about Immunofluorescence, Western Blot, and CRISPR-Cas9. In 2020-2021 the IgNITE community grew internationally with 570 high school and university students across the world participating in the competition. In this booklet we present the Top 40 teams and invite you to visit our website (www.ignitecompetition.org) to watch their pitch proposal videos. We hope you enjoy reading through some of this year’s top proposals and invite you to join our growing community.
Highlights
The IgNITE Medical Case Competition is an annual research case competition organized by students at the University of Ottawa
We propose mitochondrial autotransplantation in OA chondrocytes as a sustainable approach to increasing the production of ATP, which is transported to the extracellular matrix and broken down into adenosine
It has already been demonstrated that mitochondria from bone marrow mesenchymal stem cells (BM-Mesenchymal stem cells (MSC)) can be taken up by OA rat chondrocytes in vitro and that ischemic rabbit cardiomyocytes can integrate isolated mitochondria injected in vivo
Summary
We will use CRISPR-Cas9 technology to incorporate FoxP3 gain-of-function mutation into CD4+ naive T cells and induce their expansion in an experimental autoimmune encephalitis (EAE) mouse model for MS. UNDERGRADUATE RESEARCH IN NATURAL AND CLINICAL SCIENCE AND TECHNOLOGY (URNCST) JOURNAL Read more URNCST Journal articles and submit your own today at: https://www.urncst.com hypothesized that the removal of MUC2 via CRISPR-Cas9 has the potential to provide a novel underlying genetic mechanism to better understand Cystic Fibrosis.
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